I was introduced to Dune: Imperium–Uprising last night, and I had fun playing it. It's a lot more complicated than the games we usually play at home, which is to say it's probably super easy if you're a hard core board gamer, but I had enough fun that my own copy is on its way.
The ecosystem around the Dune board games is a bit confusing. This game is a spinoff of Dune: Imperium. Despite sharing the "Imperium" name, it's really a standalone game; nothing else is needed to play it.
From the game's description on Board Game Geek:
Dune: Imperium Uprising is a standalone spinoff to Dune: Imperium that expands on that game's blend of deck-building and worker placement, while introducing a new six-player mode that pits two teams against one other in the biggest struggle yet.
The Dune: Imperium expansions Rise of Ix and Immortality work with Uprising, as do almost all of the cards from the base game, and elements of Uprising can be used with Dune: Imperium.
It's a spinoff with a similar name, which has its own expansions! Whatever...I'm looking forward to introducing it at our next game night.